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April 13, 2022

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Moderately or severely Immunocompromised patients are at increased risk for severe disease, hospitalization, and death from COVID-19. Many conditions and treatments can cause a person to be immunocompromised including immunosuppressive medications for cancer or autoimmune disease, solid organ or bone marrow transplants, and infections like HIV. It is very important for immunocompromised patients to continue to use layered COVID-19 prevention measures including staying up to date with vaccinations (including extra dose of primary series and boosters when eligible), pre-exposure prophylaxis (PrEP), masking with high-quality masks (e.g., N95, KN95, KF94), avoiding crowded indoor settings, social distancing, and testing when appropriate after exposure or when symptomatic.

Given that moderately or severely immunocompromised patients have increased risk for severe disease, hospitalization, and death with COVID-19 infection, even when up to date with vaccination recommendations, it is important for healthcare providers to be aware of resources for vaccination, PrEP, testing, and treatment so these patients can rapidly access these lifesaving interventions.